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This White Paper was developed to serve as a starting point for a September 2016 national meeting hosted by the U.S. Department of Health and Human Services (HHS) Office on Women’s Health (OWH) to examine prevention, treatment, and recovery issues for women who misuse, have use disorders, and/or overdose on opioids. This effort builds on the HHS Opioid Initiative aimed at reducing prescription opioid and heroin related overdose, death, and dependence.